Biosyn – University of Copenhagen


Bioactive components from by-products of food processing used in a synbiotic approach for improving human health and well-being (BioSyn)

A research project funded by the Danish Council for Strategic Research and FAPESP, Brazil

By-products and waste generated in fruits and vegetables processing, such as production of juices, pectin, starches, etc., have a significant nutritive value, containing fiber and bioactive substances. The project aims to improve utilization of the by-products and recovery of bioactive components by delivery of functional food formulations for human consumption. The by-products and waste of concern are peel, pulp and pectin from tropical fruits, besides, fiber and starches from potato processing. The by-products will be converted into multifunctional synbiotic carriers for colon-specific delivery of probiotic lactobacilli and bifidobacteria. Prebiotic potential of the food by-products, such as supporting growth of probiotics, their adhesion to intestinal cells and host immunomodulation, will be investigated using in vitro mammalian cell models. The hypothesis that prebiotics and synbiotics can beneficially modulate the gut microbiota will be tested by gastrointestinal models using microbiota profiling techniques and the next generation DNA sequencing. Microbiota studies will focus primarily on the metabolic diseases. The bioactive carbohydrate epitopes related to prebiotic action and their dynamic in intestinal environment will be determined by chromatography and carbohydrate microarrays. The multivariate statistical models will be developed to link the bioactive structures in the synbiotic products with their functionality and prebiotic capacity for prediction of health benefits. Finally, BioSyn will develop and produce a synbiotic dietary formulation based on the food by-products. The outcome of BioSyn will include a new knowledge of combined potential of synbiotic ingredients for improvement of human health and the tools to generate novel synbiotic formulations from the food by-products.

Coordinator, Denmark: Professor Lene Jespersen, University of Copenhagen
Coordinator, Brazil: Professor Susana Saad, University of São Paulo
Project period: 1 January 2014 – 31 December 2017
Funding: DKK 3,354,358